The primary search terms were: myalgic encephalomyelitis, chronic fatigue syndrome, ME/CFS, diagnosis, pathophysiology, and treatment. A comprehensive search strategy was developed using both Medical Subject Headings (MeSH) and free-text terms
MOTS-C 40mg Summary Description: MOTS-c (Mitochondrial ORF of the 12S rRNA type c) is a mitochondrial-derived peptide that plays a vital role in regulating metabolism, energy balance, and cellular stress responses
Biologically, botanical drugs can lower serum AST, ALT, TG, TC levels, reduce lipogenesis, enhance -oxidation, decrease ROS, MDA, CYP2E1, and GSSG levels, increase SOD, GST, CAT, GPx, GSH, HO-1, GR levels, thereby achieving antioxidant and anti-oxidative stress effects (Wang et al., 2016)
Written informed consent to participate in this study was provided by the participants or their legal guardian/next of kin
[67] The World Health Organization also uses 2.4 g/day as the adult recommended nutrient intake for this vitamin